On this Bob Seger Mainstreet chords page I'm going to show you the chords for this classic as well as give you a free demo on how I play this one on the acoustic.
There is also a free chord sheet in .pdf to download, lyrics you can copy from the page if you need 'em and a purchase link to the full instructions tutorial for a few bucks.
There are 8 chords you'll need to play this one and they are as follows:
For rhythm on this as you can see it's pretty much a dn-dn-up-dn-up-dn-up and repeat. When you're on the G going to the Em you can use a quick bass run on the top string.
If you watch Bob Seger play and sing this song today, you'll discover it's much too high for him vocally to sing this in the original key of D or what may have been D# (youtube videos of the original have the song slightly higher than D).
Where Bob is now is 3 frets lower in the key of B. And of course he sings it on that low end. There is a video on this from 2019 in Columbus OH. don't be fooled however because Bob is play a C chord to start this off, but all that means is his guitar is tuned down 1 fret. So the C chord is actually a B key.
In live concert you'll see a sax player taking the lead break that you hear in the beginning and middle of the song. I've duplicated it here slightly with my rhythm version.
The A chord can be substituted for an Asus4 as I'm doing in the demo. It's not a deal breaker as either chord will work.